"ketosis" vs "deep ketosis"

The term "ketosis" generally refers to a metabolic state in which the body primarily uses ketones for energy instead of glucose. In the context of the Huberman Lab, Andrew Huberman has discussed the ketogenic diet's medical relevance, particularly for treating epilepsy. He explains that when the body is in ketosis, there is a significant shift in brain metabolism where ketones are metabolized in preference to glucose. This shift can greatly reduce epileptic seizures in children with a specific type of epilepsy and is associated with increased GABA transmission in the brain. An increase in GABA, an inhibitory neurotransmitter, can suppress hyperexcitability that is characteristic of epilepsy. Additionally, depression symptoms and responsiveness to antidepressants may be influenced by the ketogenic diet through its action on GABA and brain metabolism 1.

"Deep ketosis" can be thought of as a more intense or higher level of ketosis, where the concentration of ketones in the blood is significantly higher than during standard ketosis. While the data provided does not directly address "deep ketosis," the principles that apply to ketosis regarding the shift from glucose to ketone metabolism and the effects on the brain's neurotransmitter systems likely become more pronounced with deeper states of ketosis. However, for specific details regarding "deep ketosis," a further search is necessary.