alpha gpc

Alpha-GPC is a choline supplement that can raise acetylcholine, and may support focus, cognition, and physical power. Huberman notes a possible stroke concern with chronic high-dose use, linked to TMAO. 1 2

• Doses: 300–600 mg is commonly used before workouts or focused work and has been reported to enhance power output. Cognitive studies have used up to 1,200 mg per day, divided into three 400 mg doses. 3
• Timing and frequency: Huberman says he typically takes 300 mg about three or four times weekly before workouts or cognitive work, sometimes alongside caffeine. For focus, he suggests taking it about 10–20 minutes beforehand. 4 5
• Learning and memory: For cognitive learning, he suggests a different timing approach: increasing epinephrine after learning; this transcript does not specifically recommend taking Alpha-GPC late in a learning episode or immediately afterward. 6
• TMAO and garlic: Chronic high-dose Alpha-GPC has been associated in limited studies with a possible increase in stroke risk, potentially related to TMAO. Huberman mentions 600 mg of garlic as a way to help limit TMAO increases. 7 8

In short, the suggested use is occasional and task-timed, while the long-term risk evidence is described as uncertain. 9