What is the best way to supplement glycine?

Supplementing with glycine can be effective for relaxation and improved sleep quality. Dr. Craig Koniver recommends starting with a dosage between 3000 to 5000 milligrams orally, which can help calm the nervous system and facilitate better sleep. Glycine also plays a significant role in liver detoxification, and higher dosages, like 10 grams, can enhance its calming effects without causing sedation. This dosage helps to tone down the nervous system and improves sleep quality by making liver detoxification processes more efficient during rest 1 2.

Additionally, Dr. Andrew Huberman noted his personal experience using smaller doses, around 1000 milligrams, but highlights that larger doses might be necessary to observe significant effects 2.