Apigenin
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Apigenin is a compound found in chamomile, known for its various benefits, particularly in relation to sleep and anxiety. Here are some key insights discussed by regarding apigenin:
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Anxiolytic Effects: Apigenin has been noted to have mild anxiolytic properties, helping to reduce anxiety levels. It acts primarily by calming the nervous system, influencing pathways related to GABA and chloride channels, and reducing cortisol levels, which can contribute to stress reduction, especially in the evening 1.
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Dosage Recommendations: A common dosage discussed is 50 milligrams taken about 30 minutes before bed. This timing helps heighten its effectiveness in promoting sleepiness and improving sleep quality 1 2.
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Estrogen Inhibition: Apigenin is also recognized for its anti-estrogenic effects, which may be significant for both men and women. Individuals, particularly women who want to maintain higher estrogen levels, should be cautious with its use 3.
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Synergistic Use with Other Supplements: When combined with other supplements like magnesium threonate or bisglycinate, and theanine, apigenin can create a potent sleep stack that helps facilitate better sleep. This combination works by reducing rumination and anxiety, thereby aiding the transition to sleep 2 4.
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Safety Considerations: As with any supplement, it's recommended to consult with a healthcare professional before starting apigenin, especially if you have any underlying health concerns 3.
For more detailed information about apigenin and its effects, you may refer to specific podcasts episodes like Using Cortisol & Adrenaline to Boost Our Energy & Immune System Function and Maximizing Productivity, Physical & Mental Health with Daily Tools from the .
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