Apigenin
Sources:
Apigenin is a compound found in chamomile that may have mild calming and sleep-supporting effects. It is discussed as a supplement that can reduce anxiety and help with sleep.
- Dose: A commonly discussed amount is 50 mg about 30 minutes before bed.
- Possible pathways: Apigenin may act through GABA and chloride-channel pathways, and may modestly reduce cortisol.
- Estrogen: It may have anti-estrogenic effects, so people aiming to maintain higher estrogen levels are advised to be cautious.
- Combination: It is sometimes combined with magnesium threonate or bisglycinate and theanine as a sleep-support combination.
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