NAC for colds

N-Acetyl cysteine (NAC) has been discussed by Andrew Huberman as a substance with potential benefits for preventing and treating colds and flus. He refers to a study indicating that administration of NAC could markedly decrease the incidence of clinically apparent influenza, with only 25% of participants taking NAC contracting the flu compared to 79% in the placebo group. NAC is described as increasing glutathione, its primary mechanism, which is generally beneficial for health. The discussion also mentions that NAC was once considered for removal from over-the-counter sales, but as of the time of the recording, it was still legally available in the US 1.

Dosages mentioned include taking 1200 milligrams per day, divided into two doses of 600 milligrams each, either as a preventative measure or, in Dr. Huberman's case, taking 900 milligrams three times per day upon already having a cold. He notes, however, to avoid taking NAC close to sleep due to its effects on mucus production, which may disrupt sleep 1.

Dr. Huberman emphasizes the effectiveness of NAC as a powerful mucolytic, helping to clear congestion during colds without the rebound effect that some over-the-counter decongestants may cause 2. He also points out the need for more randomized control trials to fully understand the effects of NAC 3.

In summary, the information provided on the Huberman Lab regarding NAC for colds suggests it might be beneficial both in preventing and treating symptoms, although further research is necessary. It's important to note the usage of NAC may vary based on its application as a preventative or as a treatment for existing symptoms.