Why not take high doses of tumeric

Taking high doses of turmeric, specifically its active component curcumin, can have several effects and potential risks according to Andrew Huberman on his podcast, Huberman Lab.

1. Hormonal Impact: Curcumin can affect hormonal pathways, particularly by inhibiting dihydrotestosterone (DHT). This may lead to reduced libido and other hormonal imbalances in some individuals, especially those who are sensitive to curcumin 1.

2. Exercise Adaptation Interference: Due to its potent anti-inflammatory properties, curcumin might inhibit the inflammation-induced adaptation response critical for muscle and endurance improvements following exercise. This could potentially reduce the benefits of workouts 2.

3. Interactions with Medications: Curcumin is known to inhibit cytochrome P450 enzymes, which are involved in drug metabolism. This may affect how certain medications, such as anticoagulants, work in the body, raising safety concerns for those on specific pharmaceutical treatments 1.

Although curcumin is generally safe at high doses for most people, these factors highlight why caution is advised when considering high amounts of turmeric supplementation. Consultation with a healthcare provider is recommended before making any significant changes to supplement regimens.