Psilocybin and predisposition to psychosis

Yes. Psilocybin is considered unsuitable for people with psychosis or bipolar predispositions because it may destabilize them and trigger psychiatric problems that persist beyond the drug experience. 1

1. First-degree relatives: A first-degree relative with bipolar disorder, schizophrenia, or schizotypal issues can be enough to exclude someone from a clinical study, out of concern for triggering a psychotic episode that could last beyond the session. 2

2. Persistent psychiatric problems: When prolonged psychiatric problems occur after a psychedelic experience, they may resemble a manic episode; the concern is that the experience can destabilize someone with an underlying susceptibility. 3

3. Adults aged 25 and older: The guidance is framed primarily around adults 25 and older; the discussion identifies younger people as another group that should be cautious. 4