What does it entail for a former gifted child and math wyzard to have an Extrachromosomal. I am a 35 year old woman and my nieces are neurodiverse. One lives with epilepsy and the younger one is gifted in math. Does it is passed down from the mother side? Is my brother (my nieces dad) the one who passed down the gifted gene? The DNA tests shows that my brother and I don’t have the epilepsy gene.

It seems there aren't any specific clips from the Huberman Lab addressing your exact question. However, based on general insights from Andrew Huberman, here is some information that might be helpful regarding giftedness and genetic factors:

Giftedness and Genetics:

1. Heritability: Giftedness, such as exceptional mathematical ability, often has a genetic component. Both parents can contribute genes associated with cognitive abilities, but it isn't strictly passed down from one side of the family. Multiple genes and environmental factors play a role 1.

2. Complex Traits: Traits like mathematical giftedness are polygenic, meaning they are influenced by many genes. Environmental factors, including education and mental stimulation, also significantly impact the development of these abilities 1.

Epilepsy and Genetics:

1. Genetic Testing: The inheritance of epilepsy can be complex and not always due to a single gene. Even if genetic tests show no specific epilepsy gene in the parents, mutations or combinations of genes can still lead to epilepsy in offspring 2.

2. Multifactorial Influence: Epilepsy can result from a combination of genetic predisposition and environmental triggers. This complexity means that even without a direct genetic link in parents, children can still be affected due to other genetic variations and influences 3.

Familial Traits:

1. Neurodevelopment: Neurodevelopmental traits, including both giftedness and conditions like epilepsy, may share underlying genetic pathways. This could explain variations within members of the same family 4.

2. DNA Inheritance: It's challenging to pinpoint whether your brother passed down specific genes because both parents contribute to their children's genetic makeup. Moreover, the expression of these traits can differ based on interactions between genes and the environment 5.

For precise genetic insights, it's advisable to consult a genetic counselor or medical professional who can interpret DNA test results and family history comprehensively.

The retrieved information does not specifically address how epilepsy is inherited according to the Huberman Lab. However, I can provide a summary based on general knowledge, which is consistent with the insights shared by Andrew Huberman on related topics:

Inheritance of Epilepsy

1. Genetic Factors: Epilepsy can have a genetic basis, with certain types associated with specific gene mutations. These can be inherited from parents or arise as new (de novo) mutations.

2. Complex Inheritance: Epilepsy often follows a complex inheritance pattern, meaning that multiple genes, along with environmental factors, can contribute to its development. It's not typically inherited in a simple Mendelian manner (like a single gene disorder).

3. Family History: Having a family member with epilepsy can increase one's risk, but this risk varies depending on the type of epilepsy. Some forms, like generalized epilepsy, have a stronger genetic component.

4. Non-genetic Factors: Environmental factors and brain injuries can also play significant roles, even in individuals without a strong genetic predisposition.

While these points provide a high-level overview, individual genetic counseling and medical advice are recommended for personalized information.