Rapamycin

Rapamycin is a compound that targets the mammalian Target of Rapamycin (mTOR) pathway and is typically used as an anticancer drug. It is also under scientific investigation for its potential to extend lifespan, a topic explored by researchers like Dr. Matt Kaeberlein and Dr. Peter Attia. These studies have involved various species, including a dog longevity project, and have raised significant interest in the longevity community. Despite these benefits, Dr. Andrew Huberman himself does not take rapamycin for lifespan extension due to its side effect profile and the current level of data supporting its efficacy for this purpose 1.

Additionally, rapamycin has shown potential in enhancing cellular immunity, which is particularly relevant in aging. This property could hypothetically assist in cancer prevention and increase longevity, supported by studies showing that animals treated with rapamycin tend to live longer and have fewer cancers. The impact of rapamycin on nutrient sensing has also been discussed as another possible mechanism through which it could extend lifespan 2.