Summarise all the negative sides of ingesting or smoking marijuana based on Andrew's episode about marijuana


The negative effects of marijuana, as outlined by , are diverse and impact several areas including cognitive function, motivation, physical health, and mental health. Here's a summary of the points made:

  • Marijuana, particularly THC, affects the hippocampus, which leads to deficits in memory, impacting short-term recall 1.
  • Smoking and vaping marijuana impair the function of capillaries and blood vessels, reducing cognitive capacity, increasing the risk of strokes, affecting lung function, leading to peripheral neuropathies, sexual dysfunction, and potentially damaging reproductive organs 2.
  • Cannabis impacts neural circuits within the basal ganglia and cerebellum which are involved in action planning and motor sequencing, leading to lesser physical mobility 1.
  • Chronic use of cannabis has been associated with increased levels of anxiety and the development of psychosis in certain individuals 3.

    Cannabis Brain Effects

    Andrew briefly explains the different brain areas that are impacted by THC and CBD, and why they have various effects. He also discusses how regardless of the strain, there is a general suppression of neural circuits within the basal ganglia and cerebellum.

    Huberman Lab

    The Effects of Cannabis (Marijuana) on the Brain & Body | Huberman Lab Podcast #92
  • THC impairs mitochondria function in the brain, causing premature brain aging, memory impairment, and amotivational states which can harm overall mental and metabolic health 4.
  • Persistent presence of THC and CBD in bodily tissues can be detected for up to 80 days after ingestion, making it a concern for individuals who get tested for work or sports 5.
  • Chronic cannabis use alters speech patterns, including tone of voice and inflection, with chronic use defined as regular use over time of twice a week or more 6.

These points illustrate the variety of negative consequences associated with marijuana use. Andrew emphasizes the need for caution and awareness of the impacts, especially among chronic users and for particular health considerations.