Melatonin and affects on dopamine

Melatonin has notable effects on dopamine levels, as Andrew Huberman discusses. Here are the key points:

1. Dopamine Reduction: Melatonin can lower baseline dopamine levels. A study highlighted by Dr. Huberman observed a statistically significant decrease in dopamine levels 60 minutes after administering melatonin 1.

2. Circadian Effects: Exposure to bright light between 10:00 PM and 4:00 AM, or 17 to 24 hours after waking, can also reduce dopamine levels significantly. This effect is mediated through specific neural circuits activated by light exposure, which disrupt dopamine levels not only that night but also the following day 2.

3. Behavior and Supplementation: To maintain healthy dopamine levels, it is advised to avoid exogenous melatonin whenever possible and instead focus on behavioral adjustments and proper nutrition (e.g., adequate B vitamins) 1.

These points underline the importance of cautious melatonin use and consideration of dopamine's role in overall mental health and well-being.