Discuss the potential risks associated with peptide use.

Peptide use carries several potential risks, particularly if not sourced or administered properly. Andrew Huberman emphasizes that peptides should ideally be obtained through a prescription from a board-certified physician. This ensures they are clean and free of contaminants like lipopolysaccharides (LPS), which can trigger immune responses and lead to complications if accumulated over time. Peptides obtained from gray or black market sources might not be as pure or may even be mislabeled, posing significant health risks 1.

Specific peptides, particularly those that stimulate growth hormone pathways, come with their own set of risks. They can potentially increase the risk of tumor growth and exacerbate existing cancers due to their role in promoting cell growth broadly. Additionally, such peptides could cause cosmetic changes, like thickened facial features or a "distended gut" appearance, due to alterations in body composition and tissue growth 2.

Peptides that impact mood and libido can also have side effects, including nausea and increased blood pressure, particularly for those affecting melanocyte-stimulating hormones. Individuals with conditions like melanoma need to be especially cautious when using peptides that stimulate melanocytes 3.

Overall, while peptides hold promise for therapeutic use, they are potent compounds with significant effects and potential risks that require careful consideration and professional guidance 4.