In some Episode Huberman mentioned negatieve influence of cbd on sleep. Can you tell me more

The data from Huberman Lab suggests a nuanced perspective on CBD's impact on sleep.

1. Dosage and Purity Concerns: Low doses of CBD (around 5-10 mg) can promote wakefulness and consequently disrupt sleep. Conversely, higher doses (above 25 mg) may promote sleepiness and sedation. However, there's a significant concern regarding the purity and accuracy of CBD supplement labeling, which often does not match the actual content 1 2.

2. Potential Mechanisms: CBD might assist in sleep through several mechanisms:

   • Anxiolytic Effects: CBD can reduce anxiety, potentially making it easier to fall asleep.
   • Thermoregulatory Effects: Some studies suggest that CBD may reduce core body temperature, which can promote sleep.
   • Adenosine Signaling: Although less clear, CBD might interact with the brain's adenosine system, which plays a role in sleep regulation 3 2.
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       CBD and Sleep

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       CBD and Sleep

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       CBD and Sleep

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       CBD and Placebo Effects

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3. Placebo Effect: There is contention that many of the reported benefits of CBD may be attributed to placebo effects rather than direct physiological impacts. The doses that produce clinically relevant outcomes in conditions like epilepsy are much higher than common over-the-counter doses used for sleep, leading some experts to argue that lower doses might not be genuinely effective 4.

4. General Advice: Andrew Huberman and other experts, like Matthew Walker, suggest that while CBD shows promise and may not have the detrimental effects on REM sleep seen with THC, more research is needed to provide definitive conclusions on its efficacy and safety for sleep 1 2.

In summary, while CBD could help with sleep at higher doses and through specific mechanisms, its unregulated nature and potential for placebo effects mean more robust, regulated studies are essential to confirm these benefits.