Bupropion
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Bupropion, commonly known by its commercial name Wellbutrin, is a medication often used for treating depression and aiding smoking cessation. explains that Bupropion increases the release of dopamine and norepinephrine, which helps alleviate withdrawal symptoms associated with quitting smoking. This mechanism makes it useful for people who experience depression or those seeking to quit nicotine dependency. Bupropion, unlike SSRIs, tends to avoid sexual side effects but carries risks like increased seizure chances, especially in those with certain health conditions like liver or renal issues, which necessitates careful medical oversight when prescribed [1].
Bupropion's efficacy in smoking cessation moves success rates from about 5% to 20%. It's particularly noted for its capacity to maintain sufficient dopamine levels to buffer the withdrawal impacts, which include mood reduction and other withdrawal symptoms [1].
In the broader context of treating depression, Bupropion is often chosen for people who cannot tolerate SSRIs due to their side effects, such as libido reduction or appetite changes [2] [3]. While it provides significant relief for some, it's important to acknowledge its potential side effects and the need for appropriate medical guidance in its use [2].
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