I have a question about this episode Dr. David Sinclair: The Biology of Slowing & Reversing Aging | Huberman Lab Podcast #52 and this Methylene Blue Insights What do other experts say about ingesting methylene blue for health purposes as discussed in the episode Dr. David Sinclair: The Biology of Slowing & Reversing Aging | Huberman Lab Podcast #52?

Dr. Craig Koniver presents methylene blue as a possible cognitive and mitochondrial enhancer, but its effects and safety warrant caution. 1 2

• 1. Mild MAOI activity: Koniver says methylene blue acts as a mild monoamine oxidase inhibitor, which may let serotonin remain active longer in the synapse. Dr. Chris Palmer adds that excessive dosing can trigger serotonin syndrome, which can be serious and, in extreme cases, fatal. 3 4
• 2. Carbon monoxide poisoning and antiviral effects: Koniver describes methylene blue as a treatment used for carbon monoxide poisoning, helping red blood cells displace carbon monoxide and carry oxygen. He also reports hearing of antiviral effects, including anecdotal reports involving COVID-19; these are presented as observations, not established proof. 5 6
• 3. Mitochondrial function: Koniver says methylene blue binds to cytochrome c oxidase and characterizes it as helping oxygen uptake. Palmer describes it as an electron acceptor and donor that may shuttle electrons and reduce harmful electron leakage, while cautioning that too much could create reductive stress. 7 8
• 4. Dose and timing: Koniver suggests no more than 10 mg, taken in the morning, as a cognitive-enhancement dose. 9
• 5. Blue or green discoloration and broader safety: Koniver says urine may turn blue or green for about 24 hours, and liquid forms can temporarily stain the mouth. Palmer also mentions blue staining and advises using a reputable source and a sensible method of use. The color change is described, but the discussion does not establish that it is harmless; Palmer emphasizes the potential for serious risks such as serotonin syndrome. 10 11