Turkestrone

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What is Turkestrone?

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Turkestrone, also called Turkesterone, is a type of ecdysteroid, a group of hormones that play a role in growth and development. According to Kyle Gillett, these ecdysteroids are produced in places such as the adrenal glands and testes in men and in the ovaries and adrenal glands in women. After menopause, women continue to produce similar hormones from their adrenal glands. Turkestrone, when crossing the blood-brain barrier, can act as a GABA agonist, which can help improve sleep 1.

For a deeper understanding, you might want to explore the episode "Hormones and Sleep" from the , specifically involving the discussion between and Kyle Gillett.

Hormones and Sleep

Hormonal balance plays a crucial role in sleep quality, with growth hormone deficiency directly affecting sleep patterns. As individuals age, hormonal changes, particularly during menopause and andropause, can lead to sleep disturbances. Progesterone's ability to act as a GABA agonist highlights its potential benefits for improving sleep, especially in women post-menopause. Understanding these hormonal influences can provide valuable insights for those struggling with sleep issues.
Huberman Lab
Dr. Kyle Gillett: How to Optimize Your Hormones for Health & Vitality | Huberman Lab Podcast #67
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Fadogia

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Fadogia agrestis is an herb known for its potential effects on hormone levels, particularly testosterone. According to , Fadogia agrestis may increase luteinizing hormone (LH), which then boosts testosterone and estrogen production in both males and females. It's typically taken in dosages of around 600 milligrams per day, with many users reporting elevated libido, sperm production, and hormone levels 1.

However, it's vital to follow dosage guidelines and consider cycling the supplement to avoid potential toxicity. Excessive doses have been linked to toxicity in testicular cells in animal studies, though such effects require very high dosages. A common recommendation is to take the supplement three weeks on, one week off, or eight weeks on, two weeks off 2 3.

Hormones and Supplements

Andrew explains the role of luteinizing hormone in the production of testosterone and estrogen, and how supplements like Fadogia agrestis can impact this pathway. He also emphasizes the importance of maintaining balanced levels of both hormones for optimal libido and overall health.
Huberman Lab
Developing a Rational Approach to Supplementation for Health & Performance | Huberman Lab Podcast
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Getting blood tests before and after starting Fadogia agrestis is essential to monitor its effects on hormone levels and ensure there are no adverse effects 2.

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