sermorelin

Sermorelin is a synthetic compound designed to mimic growth hormone-releasing hormone, and it is FDA-approved for treating short stature. It is often prescribed for its off-label benefits, such as increased vitality, muscle growth, and fat loss. Importantly, sermorelin acts by stimulating the pituitary gland to release growth hormone, thereby increasing circulating growth hormone and IGF-1 levels. Typically, it is taken at night before sleep, with dosages ranging from 200 to 400 micrograms, three to five times per week. Continuous use every day is generally discouraged to avoid desensitization 1.

Andrew Huberman shared his personal experience with sermorelin, noting that while it can enhance deep sleep, it might reduce REM sleep and cause wakefulness after use, leading him to cease regular use. This effect on sleep architecture, mainly increasing deep sleep at the expense of REM sleep, is well documented 2.

These insights emphasize the importance of weighing the potential benefits of sermorelin against its drawbacks, such as its impact on sleep quality.