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  • methylene blue

  • Sources:

    Methylene blue has been discussed on the as a substance with a variety of uses, ranging from historical applications to recent interest in its cognitive benefits. Here's a summary of the discussions:

    1. Historical and Medical Use: Methylene blue was one of the first pharmaceuticals prescribed in the U.S. and is traditionally used to treat carbon monoxide poisoning by enhancing red blood cells' oxygen carrying capacity. It binds to cytochrome c oxidase in mitochondria, thereby acting as an oxygenator 1.

    2. Cognitive Benefits: It's gaining attention for potential cognitive enhancement. Some users report improved brain function, particularly in terms of recall and memory, when taken in doses such as 10 mg in the morning. It's compared to a nootropic, aiming to boost cognitive function by affecting the mitochondria 2.

    3. Practical Considerations: Methylene blue can stain the mouth and change urine color to green or blue, providing a visual indicator of its use and metabolic effects. It's suggested that issues such as no urine color change might point to mitochondrial inefficiencies 3.

    4. Balance of Safety and Use: While it's not on some banned lists for sports, potential users are advised to check local regulations. Over-the-counter and prescription forms exist, with some clinicians advising it as a mitochondrial "insurance policy," particularly due to its mild MAOI effects, allowing neurotransmitters like serotonin to linger longer 3.

    Overall, while methylene blue shows potential for various uses, caution is recommended regarding dosage and application, and more research is required to fully understand its effects and safety in regular use.

  • Is methylene blue safe?

  • Sources:

    Methylene blue is generally considered to be safe when taken in appropriate doses, although caution is advised. Here are some key points regarding its safety and usage:

    1. Recommended Dosage: A typical recommendation is to take about 10 mg of methylene blue in the morning. It's noted for its cognitive-enhancing properties and is well-absorbed when taken orally, which differentiates it from other compounds like NAD 1.

    2. Effects on Mitochondria: Methylene blue has been shown to enhance mitochondrial function, leading to improved oxygen uptake. This can contribute to cognitive benefits, as it allows neurotransmitters like serotonin to linger longer in the synaptic cleft due to its mild MAOI (monoamine oxidase inhibitor) properties 2.

    3. Staining: One notable effect of methylene blue is that it can turn your urine blue or green, which serves as an indication of its metabolic activity. If someone does not experience this change, it may suggest an issue with mitochondrial function 2.

    4. Consultation Recommended: Despite its potential benefits, it's advisable to consult with a healthcare professional before starting methylene blue, particularly regarding long-term use and dosage tailored to individual health needs 3 4.

    5. Availability: Methylene blue is available both as a prescription medication and over-the-counter supplement, which means that while it might be accessible, users should still exercise caution and inform themselves about proper usage and potential side effects 1.

    Overall, while methylene blue can be a safe and beneficial supplement for many, awareness regarding its usage and potential effects is essential for making informed decisions.

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