Is fadogia agrestis safe?

Fadogia agrestis’s safety—especially with long-term use—is not established, so caution is warranted. 1

• High-dose animal findings: Rat studies reported toxicity to testicular cells; the relevance to typical human doses is uncertain. 2
• Suggested cycle: One proposed regimen is three weeks on, followed by one week off. 3
• Human safety and monitoring: Long-term human safety evidence is limited. Blood work can help monitor for adverse effects, and a physician should be involved. 4 5