how does one lower apob levels

Lowering ApoB levels typically involves a combination of dietary changes, managing insulin resistance, and possibly pharmaceutical interventions:

1. Nutrition: Addressing insulin resistance by adjusting the diet can significantly decrease ApoB levels, particularly by lowering triglycerides, which is closely related to carbohydrate intake.

2. Carbohydrate Restriction: Reducing carbohydrate intake is very effective at lowering triglycerides, subsequently reducing ApoB levels.

3. Exercise: Combinations of resistance training and cardiovascular exercise can improve insulin sensitivity, which in turn can lower lipid levels, including ApoB 1.

4. Pharmacotherapy: When these lifestyle interventions are not enough to achieve the desired ApoB level, pharmaceutical approaches become necessary. Medications like statins are typically utilized to reduce cholesterol synthesis in the liver. With the liver detecting lower cholesterol levels, it pulls LDL from circulation, thus lowering LDL and ApoB levels 2.

Global recommendations for reducing ApoB levels to prevent atherosclerosis aim for levels similar to those present at birth. This level is around 20 to 30 mg/dL and is not achievable by diet alone. Pharmaceutical options, including statins and PCSK9 inhibitors, are effective for lowering ApoB but should be considered in consultation with a healthcare provider 3.

It's important to note that addressing ApoB levels is a strategic intervention, as they are a causative agent of atherosclerosis 4. Always consult a healthcare professional before starting any new treatments or making significant lifestyle changes.