AMA #9: Kratom Risks, Does Infrared Sauna Work & Journaling Benefits

Addiction Risks

Kratom, a substance derived from the mitragyna speciosa tree, is gaining attention for its addictive properties. Andrew Huberman warns against its use, highlighting its potential to become habit-forming, similar to other opioids like morphine and hydrocodone 1. He emphasizes that while some individuals have used kratom to wean off more potent opioids, the risk of addiction remains significant 2.

It is impossible to get addicted to a substance that you've never consumed.

--- Andrew Huberman

Huberman advises those who haven't tried kratom to avoid it, as its addictive potential is real and concerning 3.

   

Dual Nature

Kratom's dual nature as both an addictive substance and a tool for managing opioid addiction sparks controversy. Andrew Huberman notes that while kratom can help some individuals taper off stronger opioids, it is itself addictive, especially at higher doses 4. The debate is polarized, with some users reporting severe addiction and withdrawal symptoms, while others claim it aids in opioid recovery 5.

Kratom itself can be a useful tool for getting off other opioids.

--- Andrew Huberman

The lack of regulation over kratom supplements adds to the complexity, raising concerns about its safety and efficacy 6.

   

Opioid Effects

Kratom functions as an opioid in the body, affecting brain chemistry similarly to morphine and hydrocodone. Andrew Huberman explains that kratom activates the mu-opioid receptor, leading to effects like mild sedation and euphoria 7. Despite claims that kratom is less addictive, it indirectly triggers reinforcement circuits involving dopamine and serotonin, contributing to its addictive potential 8.

Kratom is simply not a benign substance.

--- Andrew Huberman

Huberman cautions that kratom's respiratory risks increase with dosage, especially when combined with other substances, making it a potentially dangerous opioid alternative 9.