Ben Lynch- MTHFR, Over Methylation, Histamine & Asthma

Enzyme Function

Dr. Ben Lynch emphasizes the importance of understanding enzyme function and the role of cofactors in enhancing their performance. He explains that enzymes like COMT can be influenced by compounds such as quercetin, which can either slow or enhance enzyme activity depending on the individual's biochemical makeup 1. This complexity requires a personalized approach to treatment, as Lynch notes, "You got to think of the big picture" when considering the effects of various substances on enzyme function.

If you take an enzyme that is not functioning very well and you give additional cofactor, then that enzyme should perform better.

--- Dr. Ben Lynch

Lynch also highlights the multifaceted nature of enzyme interactions, stressing that multiple genes and cofactors are involved in these processes 2.

   

Cofactors Impact

The discussion extends to specific enzymes like COMT and the impact of cofactors such as SAM-e on their function. Lynch points out that while SAM-e can enhance enzyme activity, it can also have negative effects if not balanced with other nutrients 3. He warns against using SAM-e indiscriminately, as it can increase homocysteine levels, potentially leading to adverse health effects.

If you give the same and they do worse, and SAM-e is also known to increase homocysteine, so it can be potentially very dangerous.

--- Dr. Ben Lynch

Additionally, Lynch discusses the role of glutathione as a master antioxidant that supports enzyme function by reducing oxidative stress, which is crucial for maintaining methylation processes 4.