10. The ULTIMATE bloodwork podcast!

Hormone Troubleshooting

Nathan Owens shares his experience troubleshooting low testosterone levels, highlighting the importance of measuring luteinizing hormone (LH) and follicle-stimulating hormone (FSH) alongside testosterone. He explains that low LH can indicate secondary hypogonadism, often linked to factors like nutrient intake and sleep. Paul Saladino emphasizes the need to identify the root cause of low testosterone before considering supplementation, noting that sleep deprivation and caloric restriction can significantly impact hormone levels 1.

We need to be looking for the cause of the low testosterone before we're supplementing men of all ages with testosterone. This is nuts.

--- Paul Saladino

Nathan quadrupled his testosterone by improving his sleep and increasing his calorie intake, though he acknowledges the complexity of pinpointing the exact cause 2.

   

SHBG and Libido

Paul Saladino and Nathan Owens discuss the role of sex hormone-binding globulin (SHBG) in testosterone regulation. SHBG binds to free hormones, affecting their activity, and its levels can indicate various health conditions. Nathan's SHBG levels were within the normal range, which Paul attributes to his insulin sensitivity 3.

The reason we think about sex hormone binding globulin is because it binds up free hormones.

--- Paul Saladino

They also explore the relationship between testosterone levels and libido, noting that low testosterone can impact sexual function in both men and women. However, tissue sensitivity to hormones plays a crucial role, and adequate caloric intake and stress management are essential for maintaining healthy testosterone levels 4.