
Essentials: Breathing for Mental & Physical Health & Performance | Dr. Jack Feldman
Dr. Jack Feldman, a Distinguished Professor of Neurobiology at UCLA, joins to unravel the fascinating mechanics of breathing. He explores how our breath influences mental states, including anxiety reduction and emotional resilience. Feldman shares practical techniques like box breathing and highlights the importance of the diaphragm in respiration. He also discusses the cognitive benefits of magnesium L-threonate and its potential for improving mental clarity. Tune in for a deep dive into how mastering breath can enhance overall well-being.
Top snips
How breath is generated
0:36 – 3:08
Breathing is a rhythm created by brainstem circuits and muscles.
- The pre‑Bötzinger complex in the brainstem initiates each inhale.
- The diaphragm contracts, the ribcage expands, and air flows in.
- At rest, exhalation is largely passive as the lungs recoil.
Every breath begins with neurons in this region beginning to be active.
— Jack Feldman
Nose vs mouth — why it matters 🏽 vs
3:39 – 4:23
Nasal breathing is the resting default; mouth breathing kicks in when you need more air.
- The nose filters and provides rhythmic olfactory input to the brain.
- The mouth offers larger airways for heavy ventilation (exercise).
- Diaphragm and intercostal activation are largely agnostic to nose vs mouth.
Clearly, there are differences between nasal and mouth breathing.
— Jack Feldman
Why we sigh — every ~5 minutes
14:32 – 18:22
You sigh roughly every five minutes to keep tiny alveoli from collapsing.
- Lungs contain ~500 million alveoli that can slowly collapse.
- A physiological sigh (deep inhale) pops them open and preserves surface area.
- Historical ventilator data: occasional big breaths lowered mortality in polio patients.
You sigh about every five minutes.
— Jack Feldman
Breath controls emotion & fear circuits
23:33 – 24:33
Breath patterns can reshape fear and emotional circuits.
- In mice, 30 min/day of slowed breathing for 4 weeks caused much less freezing in fear tests.
- Pathways: olfactory rhythm, vagus signals, CO2/pH, and volitional motor commands.
- Rodent data bypasses human placebo concerns, showing real neural change.
The ones that went through our protocol froze much, much less.
— Jack Feldman
Practical tool: Box breathing — 5–10 min/day
36:46 – 38:38
A short, practical breath tool: box breathing for 5–10 minutes.
- Pattern: inhale 5s → hold 5s → exhale 5s → hold 5s.
- Use it after lunch or when you’re lagging — even 5 minutes can help performance.
- If you want variation, try doubling to 10s per phase.
I will often interrupt my day to take five or ten minutes.
— Jack Feldman
Magnesium L‑threonate & cognition
41:52 – 46:16
Magnesium L‑threonate boosts brain magnesium more effectively than common salts.
- In rodents, elevated brain Mg enhanced LTP (neuroplasticity), cognition, and longevity.
- Human double‑blind RCT in mild cognitive decline: ~8 years cognitive improvement vs ~2 years placebo after 3 months.
- Many use the commercial dose; individual labs measure blood Mg to adjust.
The people who got the compound improved eight years on average.
— Jack Feldman

