Tell me more about BPC 157 and Thymosin beta 4.

BPC 157 and Thymosin beta 4 are peptides explored for their roles in tissue repair and rejuvenation. Here's an overview of each based on the episode from the Huberman Lab:

BPC 157

• Function: BPC 157, a peptide found in gastric juices, promotes tissue repair primarily by enhancing angiogenesis (formation of new blood vessels) through upregulation of vascular endothelial growth factor (VEGF) 1 2. It is often used for injuries, but its mechanism in humans isn't fully understood 3.
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    1

    Tissue Repair Mechanisms

    00:38:56
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    2

    BPC 157 Insights

    00:32:19
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    3

    BPC 157 Insights

    00:23:17
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    4

    Peptides for Healing

    00:36:42
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    5

    BPC 157 Insights

    00:27:18
• Use and Efficacy: Despite strong anecdotal support, there is a lack of rigorous human studies to confirm its effectiveness. People typically inject it subcutaneously to benefit from systemic healing effects, even though its ability to target specific injury sites remains largely theoretical 4 5.
• Concerns: The enhancement of angiogenesis could pose risks, such as stimulating tumor growth. Hence, careful consideration and health monitoring are advised if considering its use 1 2.

Thymosin Beta 4

• Function: Thymosin beta 4 (sometimes referred to as TB 500) is known to promote tissue repair and stem cell proliferation without impacting growth hormone pathways. It's linked to wound healing by increasing the resilience of tissues through the extracellular matrix 4 1.
• Use and Efficacy: This peptide is naturally produced by the thymus, which is more active in children, correlating to their quicker wound healing abilities. Its lab-synthesized form is used in adults to mimic these effects for tissue repair and rejuvenation 4.
• Potential: While animal data support its efficacy in enhancing tissue repair, comprehensive human data are lacking. Therefore, claims of its effectiveness are largely based on anecdotal evidence and warrant further research 4.

Both peptides are gaining traction for their potential benefits, yet they come with caution due to the absence of substantial human studies and possible risks, particularly regarding BPC 157. Always consult with healthcare professionals before considering such treatments.