How does lion’s mane work, how does it interact with the brain

Lion's mane mushroom primarily interacts with the brain by promoting neurogenesis and neuroplasticity. Andrew Huberman has discussed the general mechanisms through which substances like psilocybin, and potentially lion’s mane, influence the brain.

Lion’s mane contains compounds known as hericenones and erinacines, which help stimulate nerve growth factor (NGF) production. NGF is crucial for the growth, maintenance, and survival of neurons. Increased NGF can support neurogenesis—the formation of new neurons—and enhance neuroplasticity, allowing the brain to rewire its circuits and improve cognitive functions. This enhanced connectivity can lead to improved memory, focus, and higher cognitive function.

These properties make lion’s mane particularly interesting for therapeutic potential in neurodegenerative diseases and cognitive decline. Andrew Huberman emphasizes that the goal of such neuroplasticity should be adaptive, meaning that it should help improve mental processes and behaviors rather than simply causing random or maladaptive changes 1 2 3.

In summary, lion’s mane interacts with the brain by:

• Promoting the production of NGF.
• Supporting neurogenesis and neuroplasticity.
• Potentially enhancing cognitive function and offering neuroprotective effects.

There is no direct evidence or mention by Andrew Huberman of cross-tolerance between lion's mane and psilocybin. Lion's mane and psilocybin both promote neuroplasticity, but they do so through different mechanisms.

Psilocybin works by binding to serotonin receptors, particularly the 5-HT2A receptor, leading to structural and functional changes in the brain's circuitry. These effects can be significant in therapeutic contexts, such as reducing symptoms of depression and increasing neuroplasticity 1 2.

Lion's mane primarily promotes nerve growth factor (NGF) production, which supports neurogenesis and the maintenance of neurons. This mechanism is entirely different from how psilocybin influences brain activity.

Since their mechanisms are distinct, any potential cross-tolerance would require in-depth study, and as of now, Andrew Huberman has not provided evidence or discussion of such cross-tolerance.