How does lion’s mane work, how does it interact with the brain

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Lion's mane mushroom primarily interacts with the brain by promoting neurogenesis and neuroplasticity. has discussed the general mechanisms through which substances like psilocybin, and potentially lion’s mane, influence the brain.

Lion’s mane contains compounds known as hericenones and erinacines, which help stimulate nerve growth factor (NGF) production. NGF is crucial for the growth, maintenance, and survival of neurons. Increased NGF can support neurogenesis—the formation of new neurons—and enhance neuroplasticity, allowing the brain to rewire its circuits and improve cognitive functions. This enhanced connectivity can lead to improved memory, focus, and higher cognitive function.

These properties make lion’s mane particularly interesting for therapeutic potential in neurodegenerative diseases and cognitive decline. emphasizes that the goal of such neuroplasticity should be adaptive, meaning that it should help improve mental processes and behaviors rather than simply causing random or maladaptive changes 1 2 3.

Psilocybin and Brain Connectivity

Andrew discusses the use of psilocybin in rewiring the brain and expanding connectivity. He emphasizes that the goal is adaptive rewiring that leads to new ideas and ways of thinking that allow people to function better in their lives. Psilocybin seems to increase connectivity in the brain in ways that still allow people to function in their daily lives, without experiencing long-term issues with memory.
Huberman Lab
How Psilocybin Can Rewire Our Brain, Its Therapeutic Benefits & Its Risks | Huberman Lab Podcast
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In summary, lion’s mane interacts with the brain by:

  • Promoting the production of NGF.
  • Supporting neurogenesis and neuroplasticity.
  • Potentially enhancing cognitive function and offering neuroprotective effects.
RELATED QUESTIONS

Would there be any cross tollerance with lion’s mane and psilocybin?

Sources:

There is no direct evidence or mention by of cross-tolerance between lion's mane and psilocybin. Lion's mane and psilocybin both promote neuroplasticity, but they do so through different mechanisms.

Psilocybin works by binding to serotonin receptors, particularly the 5-HT2A receptor, leading to structural and functional changes in the brain's circuitry. These effects can be significant in therapeutic contexts, such as reducing symptoms of depression and increasing neuroplasticity 1 2.

Lion's mane primarily promotes nerve growth factor (NGF) production, which supports neurogenesis and the maintenance of neurons. This mechanism is entirely different from how psilocybin influences brain activity.

Since their mechanisms are distinct, any potential cross-tolerance would require in-depth study, and as of now, has not provided evidence or discussion of such cross-tolerance.

Psilocybin and Neuroplasticity

Andrew discusses how psilocybin induces both structural and functional plasticity in the human and animal brain, potentially explaining the relief from depression that people experience. He also mentions a review that goes into detail about how neurons change their excitability patterns based on the activation of the serotonin two A receptor.
Huberman Lab
How Psilocybin Can Rewire Our Brain, Its Therapeutic Benefits & Its Risks | Huberman Lab Podcast
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RELATED QUESTIONS