Nmn

NMN (nicotinamide mononucleotide) is a supplement taken as a precursor to NAD+, with the aim of increasing NAD+ levels. Whether that leads to meaningful health-span or longevity benefits remains uncertain. 1 2

• NAD+ and aging: NAD+ is involved in cellular energy production and supports sirtuin pathways linked to cellular repair; levels decline with age. 3
• Reported doses and use: Mark Hyman said he takes 1,000 mg of NMN daily. Andrew Huberman described taking NMN as a sublingual powder. 4 5
• NMN and NR evidence: NMN and NR can raise NAD+ levels, but increased levels have not been shown to produce established benefits for human health span or lifespan. 6 7
• Lifestyle factors: Exercise and fasting were described as ways to support pathways involved in NAD-related cellular processes. 8