Nmn

Nicotinamide Mononucleotide (NMN) is a supplement frequently discussed for its potential to enhance cellular health and longevity. Here are some key insights gathered from recent discussions on the topic in the Huberman Lab:

NMN and NAD+

1. Role in Aging:

   • NMN plays a crucial role in increasing levels of NAD+ (Nicotinamide Adenine Dinucleotide), which is vital for energy production and cellular repair. As we age, NAD+ levels decline, and supplementing with NMN is thought to help optimize energy levels and improve mitochondrial function 1.

2. Usage and Dosage:

   • Dr. Mark Hyman, a guest on the podcast, mentioned taking 1000 mg of NMN daily, emphasizing its role as an “optimization tool” rather than a cure-all 1. Andrew Huberman also mentioned using sublingual NMN and having occasional NAD infusions for benefits related to energy and cognitive function.

3. Comparisons to Other Supplements:

   • There is a commercial debate around NMN and its counterpart, Nicotinamide Riboside (NR). Andrew Huberman pointed out that while NMN is still sold as a supplement despite FDA scrutiny, NR has an FDA designation of "generally recognized as safe" (GRAS). This leads to differing market perceptions and availability 2.

4. Scientific Efficacy:

   • Research is ongoing about the actual benefits of NMN. Some studies have suggested minimal effects on lifespan extension, with the debate largely considered commercial rather than scientific. Peter Attia pointed out that while both NMN and NR can elevate NAD levels, the real significance lies in whether it meaningfully impacts health span—this remains inconclusive 2

5. Mechanistic Insights:

   • NMN is thought to work through pathways that involve sirtuins, proteins linked to cellular health and aging. Lifestyle factors such as exercise and fasting can also promote NAD+ production, hinting that supplementation might not be the only avenue for enhancing this crucial molecule 3.
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       1

       Healing Through Regeneration

       02:32:17
       
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       2

       NMN vs NR Debate

       01:25:31
       
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       3

       Sirtuins and Aging

       00:56:47
       

Conclusion

While NMN appears promising for supporting cellular health and combatting age-related decline through NAD+enhancement, the current consensus underscores the need for further research to substantiate claims around its effectiveness and benefits in the context of lifespan and health optimization.

For more detailed discussions and insights, you may listen to the episodes featuring Dr. Mark Hyman and Dr. Peter Attia on the Huberman Lab.