Do the protocols for raising ones dopamine levels work for people with therapy resistant depression too?

There isn’t evidence here that general dopamine-raising protocols treat therapy-resistant depression. The discussion describes cold exposure and supplements as ways to influence dopamine, but not as established treatments for treatment-resistant depression; it also cautions people taking depression medication to be careful about manipulating dopamine and to consult a clinician before changing supplements. 1 2

For treatment-resistant depression specifically, a guest describes ketamine as FDA-approved but with mixed trial results and meaningful risks, and says he would consider the SAINT rTMS protocol because he viewed its evidence more favorably. Discuss treatment options with a psychiatrist or other qualified clinician rather than trying to raise dopamine as a substitute for care. 3