AMA #12: Thoughts on Longevity Supplements (Resveratrol, NR, NMN, Etc.) & How to Improve Memory

NAD Pathway

The NAD pathway is a focal point in the discussion of longevity supplements, particularly NR, NMN, and NAD infusions. Andrew Huberman shares his personal experience with NAD infusions, noting their discomfort but also their potential benefits, such as improved sleep and vigor post-illness 1. He emphasizes that while NAD infusions are FDA-approved, their efficacy in increasing lifespan remains unproven 2. Huberman states, "I take NR and NMN, but I take it because I like how it makes me feel," highlighting the subjective nature of these supplements' effects.

   

Resveratrol Impact

Resveratrol and related supplements have been popularized for their supposed longevity benefits, but Andrew Huberman argues that this belief has largely been debunked. He explains that while resveratrol might have some positive effects on cellular function, there is little evidence supporting its role in extending lifespan 3. Huberman mentions, "I don't think resveratrol increases longevity," but he does take grape seed extract for its vascular benefits, not for its resveratrol content 4.

   

Metformin & Berberine

Metformin and berberine are often discussed in the context of longevity due to their effects on blood glucose and mTOR pathways. Andrew Huberman shares his personal experience with berberine, noting it causes him headaches, and expresses skepticism about metformin's efficacy in extending lifespan 5. He states, "I don't take metformin because...there isn't sufficient data to support taking metformin for increasing lifespan," reflecting his cautious approach to these supplements.

   

Rapamycin Research

Rapamycin is another compound under investigation for its potential to extend lifespan, but Andrew Huberman remains cautious. He acknowledges the ongoing research by experts like Dr. Matt Kaeberlein but chooses not to take rapamycin due to its side effects and insufficient data supporting its use for longevity 6. Huberman concludes, "I've listed out the things that I'm perfectly willing and happy to do...and for the time being, I've decided to stay away from metformin and rapamycin," emphasizing the importance of foundational health practices over experimental supplements.