What are the known side effects of Ozempic?

Reported side effects of Ozempic (semaglutide) include:

• Digestive symptoms: Nausea and gastrointestinal distress are recognized effects; higher doses may cause nausea, vomiting, and other stomach-related problems. 1 2
• Delayed stomach emptying: Slower gastric emptying is part of how these drugs work and is linked to nausea and vomiting. One guest also raised concerns about pancreatitis and gastroparesis, including a claim that gastroparesis may persist after stopping; this was presented as a concern, not established certainty. 3 4
• Muscle loss: Weight loss on GLP-1 drugs can include loss of muscle; clinically significant muscle loss was described as uncommon but a concern, especially for people who are not exercising or already have low muscle mass. 5 6
• Other reported concerns: Depression was raised as a possible concern, but the discussion did not establish how common or definitively caused by Ozempic it is. A guest also mentioned a very rare potential risk of vision loss in people with a particular optic-nerve vulnerability. 7 8

The specific risks and likelihood can vary; the material also emphasizes gradual dose titration and clinician guidance. 9