I’m 50 years old what supplements should I take to reverse aging


In regard to supplements for anti-aging that may be pertinent for a 50-year-old, and his guests on the have discussed several compounds and their effects on aging pathways. Here's a summary:

  • NAD Boosters: NAD levels decline with age, and boosting NAD can activate sirtuins, proteins that help protect the body and may slow aging. Resveratrol is noted as an activator of sirtuins, and supplementing with NAD precursors like NMN (Nicotinamide Mononucleotide) is a common practice for some aiming to combat aging biomarkers. Dr. David Sinclair mentions he personally takes 1 gram of NMN daily 1 2.
  • Omega-3 Fatty Acids: While not directly discussed within the context of anti-aging, omega-3 supplements have numerous health benefits, including potential anti-inflammatory effects, which could indirectly contribute to an anti-aging regimen 3.

    Anti-aging Supplements

    Andrew and David discuss molecules that impact the sirtuins pathway and how they can be incorporated into a supplementation protocol. They mention the importance of naturally boosting the activity of sirtuins through exercise and fasting, and also discuss the effectiveness of resveratrol and nad in activating sirtuins.

    Huberman Lab

    Dr. David Sinclair: The Biology of Slowing & Reversing Aging | Huberman Lab Podcast #52
  • Antioxidants & Plant-Based Compounds: David Sinclair explains how consuming stressed plants, which produce more of their own defense molecules like resveratrol, may activate our own longevity pathways. He also cautions against overdosing on antioxidants like vitamin C and vitamin E as they could interfere with necessary cellular processes 4.

Keep in mind that supplement efficacy and needs can be highly individual, and it's important to approach supplementation rationally. Measure yourself and review it with a healthcare professional to ensure what you're doing is beneficial for your unique circumstances. Also, ensure any supplements are from reputable companies and follow Good Manufacturing Practices (GMP) 2.

For a more tailored recommendation, it's important to consult with a healthcare provider, as individual health status, lifestyle, and goals should dictate the most appropriate supplement strategy. This is especially crucial for those in their 50s or older, as interactions with medications, existing health conditions, and specific nutritional needs can vary widely among individuals 5.