Testosterone replacement therapy

Testosterone replacement therapy (TRT) means treating testosterone levels that are below the reference range; using testosterone when levels are already normal to raise them further is better described as augmentation. One discussion gives a typical low level as below about 300 ng/dL, while emphasizing that symptoms and evaluation matter too. 1

• Potential trade-off for fertility: External testosterone suppresses the body’s own testicular hormone signaling and can dramatically reduce sperm production. If you may want children, discuss fertility-preserving options or stopping therapy with a qualified clinician. 2
• Dose and monitoring: A physician guest describes roughly 100–120 mg per week, divided into multiple doses, as a common starting replacement range—not a personal recommendation. He notes possible acne, hair loss, mood changes, blood-count, cardiovascular, lipid, and fertility concerns, and stresses medical monitoring. 3 4
• Before considering it: The host recommends first addressing sleep, exercise, nutrition, stress, and training; if pursuing testosterone, he advises the minimum effective dose and attention to fertility goals. 5

TRT is a medical decision that calls for individualized assessment and ongoing clinician supervision.