Glycine supplementation

Glycine may support phase-two liver detoxification and help some people settle down and fall asleep more easily.

• Liver processing: Glycine supports phase-two amino-acid conjugation, which helps the liver make compounds easier to excrete. The discussion notes that pharmaceuticals can increase activity in the liver’s phase-one P450 system, adding to the need for phase-two processing. 1 2
• Starting dose and absorption: A typical starting amount is 3–5 grams orally at bedtime. Glycine is described as well absorbed when taken orally. 3
• Sleep response: Glycine may calm the nervous system and make it easier to fall asleep, but effects can vary; one account describes using it with other sleep supplements only every few nights. 4 5