What are the known side effects of Ozempic?

Known side effects of Ozempic include gastrointestinal problems, pancreatitis, muscle loss and reported mood changes.

• Slowed stomach emptying: This can cause nausea and vomiting; one discussion also raises severe gastroparesis, which it says may persist after the drug is stopped. 1 2
• Pancreatitis: It is described as a potential risk. 3 4
• Muscle and potentially bone loss: Muscle loss is discussed as a concern with weight loss on these drugs; bone loss is raised as a possibility, but this context does not establish it as a confirmed side effect. 5 6
• Reported mood changes: Major depressive disorder has been reported in patients receiving Ozempic. A guest suggests reduced reward signaling could be involved and voices concern about depression and suicidal thoughts. 7
• Changes in cravings and impulsive behavior: Some reports and clinical observations describe reduced cravings for alcohol and other reward-seeking behaviors; these are effects, not necessarily harmful side effects. 8 9