Discuss alternatives to Zolpidem.

Alternatives discussed include low-dose doxepin, trazodone, dual orexin receptor antagonists (DORAs), short-term benzodiazepines, melatonin, and magnesium.

• Low-dose doxepin: May be especially helpful for staying asleep. Walker describes a liquid dose starting around half a milliliter, mixed into a drink during the half-hour before bed. 1
• Trazodone: Has been used to help people who struggle to fall asleep, though Walker notes community pushback; Palmer specifically cautions against it for someone who is hypomanic because it is an antidepressant. 2 3
• DORAs: Dual orexin receptor antagonists reduce wakefulness signaling, which may help address excessive wakefulness at night and support sleep. 4
• Benzodiazepines: Palmer describes using them temporarily—aiming for three to seven days of decent sleep to interrupt a poor-sleep cycle—and emphasizes getting off the medication afterward. 5
• Melatonin: Mentioned as a supplement that may be used to help with sleep; the cited discussion does not specify a dose or detailed mechanism. 6
• Magnesium: Certain forms may support falling and staying asleep; Huberman describes magnesium threonate or bisglycinate taken 30–60 minutes before bed, while noting that some people experience gastrointestinal discomfort. 7