What are NAD boosting therapies

NAD-boosting therapies are approaches intended to raise nicotinamide adenine dinucleotide (NAD), a molecule involved in cellular chemical reactions and linked to energy production and cell function. Common approaches include taking the precursors NMN or NR, or receiving NAD directly by intravenous infusion. 1 2

• NMN and NR supplements: NMN and NR are used as NAD precursors. Huberman described taking both and subjectively noticing more energy, while noting that evidence that raising NAD extends human lifespan is not established. 3 4
• David Sinclair’s NMN use: Sinclair said he takes 1 gram of NMN daily, but cautioned that his regimen may not work the same for everyone. 5
• NAD infusions: Infusions can be uncomfortable; Huberman described nausea and pressure-like discomfort during treatment. Craig Koniver described a 750 mg intravenous loading dose and discussed its history in substance-use treatment. 6 7
• Evidence and clinical investigation: Benefits are still being evaluated. Huberman noted the lack of clinical trials he knew of for NAD infusions to improve vigor or recovery after illness, while Sinclair described ongoing clinical trials involving older patients. 8 9