What are NAD boosting therapies

NAD boosting therapies focus on increasing the levels of nicotinamide adenine dinucleotide (NAD), a compound crucial for energy metabolism and cellular function. Here are some insights from the Huberman Lab on NAD-boosting therapies:

1. Supplements: NMN and NR

   • NMN (Nicotinamide Mononucleotide) and NR (Nicotinamide Riboside) are common supplements used to boost NAD levels. Dr. Andrew Huberman discusses taking these to enhance energy, although he's clear that evidence for lifespan extension is lacking. Users often report improved mental and physical energy when taking these supplements in the morning 1 2.
   • Dosage and Effects: David Sinclair mentions taking one gram of NMN daily and observes a noticeable increase in NAD levels among those who follow similar protocols, though responses can vary due to individual differences 3.
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       Energy and NAD Boost

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       NAD and Supplements

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       NMN Dosage Insights

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       NAD Infusion Experience

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       NAD Infusion Insights

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       NAD Transformations

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2. NAD Infusions

   • NAD can also be administered directly through infusions, which Andrew Huberman notes can result in improved vigor and recovery from illnesses despite being quite uncomfortable. The infusion process is often accompanied by discomfort like nausea and a feeling of pressure during the treatment 4.
   • The typical protocol for NAD infusions involves a "loading dose" of 750 milligrams intravenously to effectively support recovery, particularly in addiction scenarios 5.

3. Clinical Perspective

   • Dr. Craig Koniver emphasizes the transformative effects of NAD, which can rapidly improve health outcomes in various clinical scenarios, including chronic infections and post-illness recovery. The benefits often extend beyond what might be expected purely based on biochemistry 6.

These therapies are still being explored for their full potential and impact, with clinical trials aiming to verify their efficacy and safety for broader applications. Always consult with a healthcare provider before starting any new supplementation or therapy regimen.