I have a question about this episode Dr. David Sinclair: The Biology of Slowing & Reversing Aging | Huberman Lab Podcast #52 and this Methylene Blue Insights What do other experts say about ingesting methylene blue for health purposes as discussed in the episode Dr. David Sinclair: The Biology of Slowing & Reversing Aging | Huberman Lab Podcast #52?

Experts describe methylene blue as a possible cognitive and mitochondrial aid, but its health benefits and safety depend on context and remain uncertain.

1. Dr. David Sinclair’s skepticism: Sinclair said he was unsure why people ingest it, recalled claims of lifespan extension in smaller organisms, and raised concerns about staining and misuse of substances such as colloidal silver. 1

2. Dr. Craig Koniver’s proposed benefits: Koniver described methylene blue as acting at mitochondrial cytochrome C oxidase and as a cognitive stimulant; he also said it may have antiviral effects. 2 3

3. Koniver’s suggested use: He recommended no more than 10 mg orally in the morning and said he personally takes it about three times a week, rather than daily. 4 5

4. Caution outside medical supervision: Chris Palmer warned that excessive dosing can cause reductive stress and serotonin syndrome, which can be serious; he advised using a reputable source and taking it in a sensible way. 6 7