How does it enhance cognition?

Methylene blue is described as potentially enhancing cognition by supporting mitochondrial activity and altering neurotransmitter signaling.

• Oxygen and mitochondria: It may help hemoglobin carry more oxygen and interact with mitochondrial machinery, potentially supporting neuronal energy production and cognitive function. 1
• Neurotransmitters: As a mild monoamine oxidase inhibitor, it may let serotonin remain active longer in the synaptic cleft; the discussion also describes a cognitive-enhancing effect. 2
• Reported effects and timing: The guest calls it a cognitive stimulant and reports that people using a formulation with caffeine and B vitamins describe improved brain function and memory. The discussion does not specify how quickly cognitive effects occur. 3
• Dose and visible effect: The suggested dose is no more than 10 mg in the morning; it can turn urine green or blue for roughly 24 hours. 4