What Antidepressant Withdrawal Is Really Like | EP 171 Brooke Siem

Topics covered
Popular Clips
Questions from this episode
- Asked by 29 people
- Asked by 28 people
- Asked by 25 people
- Asked by 16 people
- Asked by 6 people
- Asked by 1 person
Episode Highlights
Physical Symptoms
Brooke Siem shares her intense physical symptoms during antidepressant withdrawal, particularly from Effexor. She describes a moment in New York City when her senses became overwhelmingly heightened, making rain feel like bullets on her skin 1. Mikhaila Peterson adds that dietary changes can also trigger similar sensory overloads, attributing some of her withdrawal symptoms to food reintroductions 2.
All of a sudden, like, in one moment, all of my senses intensified. The rain was coming down, and it felt like bullets on my skin.
---
Both emphasize the importance of understanding these physical reactions to better manage withdrawal.
Emotional Symptoms
The emotional toll of antidepressant withdrawal is profound, with Brooke experiencing violent, intrusive thoughts and severe mood swings. She recalls locking herself in her apartment, fearing she was losing her mind 3. Mikhaila discusses her own emotional upheavals, including attributing withdrawal symptoms to dietary changes and struggling with hallucinations 4.
I thought I was absolutely crazy. Like, obviously, I needed to be on psychiatric medications because this is who I am on the inside.
---
Both women highlight the psychological challenges and the need for awareness and support during this difficult process.
Coping Strategies
Coping with withdrawal requires a multifaceted approach. Brooke emphasizes the brain's ability to heal over time, likening the process to recovering from long-term alcohol use 5. Mikhaila suggests using compounding pharmacies to taper off medications gradually, reducing the risk of severe withdrawal symptoms 6.
The brain is amazing. It's plastic, it's malleable. It can change. It just needs time, and you have to give it time.
---
Both stress the importance of patience and proper medical support in navigating the withdrawal journey.
Related Episodes

Understanding & Conquering Depression | Huberman Lab Podcast #34
Answers 383 questions
The Science & Treatment of Bipolar Disorder | Huberman Lab Podcast #82
Answers 383 questions

Dr. Karl Deisseroth: Understanding & Healing the Mind | Huberman Lab Podcast #26
Answers 383 questions
The Science of MDMA & Its Therapeutic Uses: Benefits & Risks | Huberman Lab Podcast
Answers 383 questions
Tools for Managing Stress & Anxiety | Huberman Lab Podcast #10
Answers 383 questions

Dr. Chris Palmer: Diet & Nutrition for Mental Health | Huberman Lab Podcast #99
Answers 383 questions

Dr. Anna Lembke: Understanding & Treating Addiction | Huberman Lab Podcast #33
Answers 383 questions

Dr. Paul Conti: How to Improve Your Mental Health | Huberman Lab Guest Series
Answers 383 questions














