How to lose weight

Thyroid Impact

Paul discusses the detrimental effects of seed oils, particularly linoleic acid, on thyroid function. He cites studies showing that linoleic acid inhibits thyroid hormone binding, potentially leading to thyroid dysfunction. Paul emphasizes the lack of research in this area due to funding biases and highlights his efforts to promote unbiased nutritional research through the Animal Based Nutrition Research Foundation 1.

Linoleic acid significantly inhibited the ability of T3 triiodothyronine, the active form of thyroid hormone, to bind to its nuclear receptor in these nuclei.

--- Paul Saladino

He also discusses the role of omega-6 fatty acids in obesity, noting that high intake during early development can lead to increased fat cell formation and adiposity later in life 2.

   

Dietary Patterns

Paul explains how processed foods, refined sugars, and grains disrupt our evolutionary dietary patterns, leading to obesity and metabolic disorders. He shares an anecdote about the Hadza tribe to illustrate the impact of a Westernized diet on traditionally healthy populations 3.

Even hunter-gatherers can get fat if they eat a westernized type diet.

--- Paul Saladino

Paul advises against calorie-restricted diets, advocating instead for improving dietary quality by eliminating seed oils and processed foods to achieve sustainable weight loss 4.