EPISODE #982 How Butyrate Supports Gut, Cell & Brain Function - Jessica Kane Berman / BodyBio

Gut Health

Butyrate plays a crucial role in maintaining gut health by nourishing colonocytes, the cells lining the gut wall, and supporting the expression of tight junctions to prevent leaky gut. Jessica Kane Berman explains that butyrate is a byproduct of bacterial fermentation of resistant starch, which is often lacking in modern diets 1. This short-chain fatty acid also influences the mucous layer of the gut lining, enhancing its protective function.

Butyrate is one of the most important players in this entire equation.

--- Jessica Kane Berman

Additionally, butyrate impacts the gut-brain axis and gene expression, acting as a histone deacetylase inhibitor to protect DNA from everyday toxins 2.

   

Metabolic Benefits

Butyrate offers significant metabolic and immune benefits, including effects on insulin resistance and inflammation. Jessica Kane Berman highlights that postbiotics, like butyrate, are beneficial in regulating blood sugar and metabolic diseases, with doses ranging from 2.5 to 5 grams daily being therapeutic 3. The compound also plays a role in reducing systemic and colonic inflammation, making it a valuable addition to one's health regimen.

It's super physiological doses that are really beneficial and therapeutic.

--- Jessica Kane Berman

Experimenting with different forms of butyrate, such as sodium or calcium magnesium butyrate, can help individuals find what works best for their specific needs 4.