The Effects of Cannabis (Marijuana) on the Brain & Body | Huberman Lab Podcast #92

Anxiety & Depression

Cannabis use, particularly with THC, initially provides anxiety relief, but over time, its effectiveness diminishes. Andrew Huberman explains that regular use, more than twice a week, leads to a decrease in the number of available CB1 receptors, requiring higher doses for the same effect 1. This adaptation can result in increased anxiety and depression, even during cannabis use. Huberman notes, "Depression is not a strong predictor of seeking out cannabis, but cannabis use makes people four times likelier to develop a chronic major depression."

Depression is not a strong predictor of seeking out cannabis, but cannabis use makes people four times likelier to develop a chronic major depression.

--- Andrew Huberman

Additionally, the legal status of cannabis can obscure its health risks, leading to assumptions of safety that aren't always accurate 2.

   

Psychosis Risk

Chronic cannabis use is linked to a heightened risk of developing psychosis, especially in individuals with genetic predispositions. Andrew Huberman highlights a study from "Lancet Psychiatry" showing that frequent cannabis use can quadruple the risk of psychosis, particularly schizophrenia and bipolar-like episodes 3. This risk is exacerbated by the high THC potency in modern strains. Huberman warns, "The more potent the THC concentration, the higher probability of developing psychosis or a major depressive episode."

The more potent the THC concentration, the higher probability of developing psychosis or a major depressive episode.

--- Andrew Huberman

Furthermore, cannabis use during adolescence can impair neural circuits, leading to cortical thinning and cognitive issues 4.