152. More myth debunking: TMAO, Neu5gc, Methionine/Glycine balance

Dietary Balance

Paul Saladino discusses the balance of methionine and glycine in our diets, emphasizing the importance of consuming both amino acids in appropriate amounts. Methionine is abundant in muscle meat, while glycine is found in collagen and connective tissues. Paul explains that some plant-based proponents argue for methionine restriction to extend life, but he believes this is based on animal studies and not applicable to humans 1.

Except that's not really the case. You will just become malnourished, very skinny, angry, irritable and generally kind of weak.

--- Paul Saladino

He also shares his personal experience of adding collagen to his diet when he was on a strict carnivore diet, but now believes that consuming meat with connective tissues provides sufficient glycine 2.

   

Health Impact

Paul explores the health implications of methionine and glycine consumption, focusing on their effects on oxidative stress and longevity. He highlights studies showing that glycine supplementation can extend the lifespan of mice and mitigate methionine toxicity 3.

Glycine supplementation extends lifespan of male and female mice.

--- Paul Saladino

Paul argues that instead of restricting methionine, we should ensure adequate glycine intake by consuming cuts of meat with connective tissue or supplementing with glycine if necessary 4.